Crystal structure of the human GINS complex
نویسندگان
چکیده
منابع مشابه
Molecular architecture of the human GINS complex
Chromosomal DNA replication is strictly regulated through a sequence of steps that involve many macromolecular protein complexes. One of these is the GINS complex, which is required for initiation and elongation phases in eukaryotic DNA replication. The GINS complex consists of four paralogous subunits. At the G1/S transition, GINS is recruited to the origins of replication where it assembles w...
متن کاملCrystal structure of the GINS complex and functional insights into its role in DNA replication.
The GINS complex, which contains the four subunits Sld5, Psf1, Psf2, and Psf3, is essential for both the initiation and progression of DNA replication in eukaryotes. GINS associates with the MCM2-7 complex and Cdc45 to activate the eukaryotic minichromosome maintenance helicase. It also appears to interact with and stimulate the polymerase activities of DNA polymerase epsilon and the DNA polyme...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2007
ISSN: 0890-9369
DOI: 10.1101/gad.1548107